Allergic Interstitial Pancreatitis in Rats Injected with Guinea Pig Anti-insulin Serum

Abstract

The diabetic syndrome induced in rats by guinea-pig anti-insulin serum is complicated by interstitial pancreatitis similar in several respects to that seen in some infants born of diabetic mothers. It is characterized by lesions in the exocrine portion of the gland which include eosinophilic infiltration (73 per cent), edema (54 per cent), and focal areas of necrosis (15 per cent) or hemorrhage (14 per cent). Its appearance is not related to the severity of the induced diabetes and its nature suggests that it is allergic in origin. Other histological findings are consistent with previous observations and similar to those encountered in human and other forms of experimental diabetes.