Affiliation:
1. Department of Pediatrics, University of Minnesota Medical School Minneapolis, Minnesota
Abstract
Skin specimens obtained from 24 insulin-dependent diabetics (IDD) and 35 controls were examined by immunofluorescence (IF) microscopy. An increased percentage (>8%) of dermal vessel basement membranes (BM) showing circumferential fluorescence for albumin was observed in 18 of 24 IDD (duration of diabetes 1.5–33 yr) and 1 of 35 controls. Dual label studies using fluorescein-conjugated anti-human albumin and rhodamine-conjugated anti-human BM confirmed that localization of albumin was within the BM. These studies suggest that increased albumin localization in extracellular BM may be widespread in diabetes.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
20 articles.
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