Progression of Retinopathy in Insulin-Treated Type 2 Diabetic Patients-Reference-Cited by-同舟云学术

Progression of Retinopathy in Insulin-Treated Type 2 Diabetic Patients

Published:2002-02-01 Issue:2 Volume:25 Page:381-385
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Henricsson Marianne¹,Berntorp Kerstin²,Fernlund Per³,Sundkvist Göran²

Affiliation:

1. Department of Ophthalmology, University Hospital, Malmö, Sweden

2. Department of Endocrinology, University Hospital, Malmö, Sweden

3. Department of Clinical Chemistry, University Hospital, Malmö, Sweden

Abstract

OBJECTIVE—To study the progression of retinopathy 3 years after initiation of insulin therapy. RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured. RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels. CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/25/2/381/649448/dc0202000381.pdf

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