Affiliation:
1. Laboratoire de Physiologie métabolique et de la Nutrition, Institut de Biologie, Université d'Alger Algerie
2. Institut de recherches Servier Suresnes, France
3. Unite de Recherches de Nutrition et Métabolisme des lipides, Université Paris-Val-de-Marne Créteil, France
Abstract
It has been reported that sand rats, naturally feedingon low-caloric-value plants containing a high concentration and develop hyperglycemia when fed on a standard laboratory diet. The aim of this study was to examine the long-term effects of a synthetic-chow diet on the metabolic pattern of the diabetic syndrome in a large group of sand rats. While a few animals had a fulminant reaction with markedly decreased glucose tolerance, low plasma insulin levels, and death within 3–4 wk, most sand rats developed obesity and elevated plasma insulin levels. From the third month and forward, 40% of sand rats presented with a diabetic syndrome with hyperinsulinemia, hyperglycemia, markedly decreased glucose tolerance, and insulin resistance. This diabetic syndrome can be compared with maturity-onset (type II) diabetes. When this synthetic-chow diet was given for more than 6 mo, the majority of animals lost considerable weight and showed a major depletion of fat stores. Serum immunoreactive insulin levels fell, while blood glucose rose to above 500 mg/dl with glycosuria and ketonuria. The elevated triglyceride content of plasma and the lipid deposits in the liver were greatly augmented, and no glycogen was present. Animals developed frank insulin-dependent diabetes, and diabetic animals not treated with insulin died in diabetic coma with presumed ketoacidosis. The disease was essentially confined to sand rats showing abnormal glucose tolerance, even before eating laboratory chow. This observation suggests a genetic factor. Thus, the sand rat appears to be a potentially interesting model for investigation of both maturity-onset and insulin-dependent diabetes.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Gerbil, Psammomys obesus, a human-like rodent model of eye research;Rodents and Their Role in Ecology, Medicine and Agriculture [Working Title];2023-09-08
2. Contribution of animal models to diabetes research: Its history, significance, and translation to humans;Journal of Diabetes Investigation;2023-07-03
3. Progress in research on the reproductive function in the sand rat (Psammomys obesus): A review;General and Comparative Endocrinology;2023-01
4. Potential Applications of Thyroid Hormone Derivatives in Obesity and Type 2 Diabetes: Focus on 3,5-Diiodothyronine (3,5-T2) in Psammomys obesus (Fat Sand Rat) Model;Nutrients;2022-07-25
5. Apoptosis in epididymis of sand rat Psammomys obesus, Cretzschmar, 1828: Effects of seasonal variations, castration and efferent duct ligation;Morphologie;2021-12